Behcet's disease is an inflammatory disorder that affects multiple body organs. It's named for the Turkish dermatologist Dr. Hulusi Behcet who described the disease.

The cause of the disease still unclear, but some studies suggested that immunological and genetic factors play an important role.

The clinical picture of Behcet's disease consists of the following:

• Mouth ulcers: it's the most common clinical sign of Behcet's disease.
• Genital ulcers: it's relatively less common than mouth ulcer; it affects mainly adults. Genital ulcers are observed in testicles and penis for males, while in females it's commonly seen in the external genitalia, but sometimes it affects vagina and cervix.
• Dermatological signs: acne-like skin rash on both legs.
• Eye problems: conjunctivitis, retinitis and progressive impairment of vision.
• Arthralgia: it's the main patient's complain, which affects mainly knee and wrist joints. For this reason, many cases of Behcet's disease are misdiagnosed as rheumatic arthritis.
• Neurological signs: increased intracranial pressure, convulsions, chronic headache, meningitis, optic neuropathy.
• GIT problems: many patients with Behcet's disease are manifested with irritable bowel disease associated with many GIT symptoms such as; abdominal pain, bloating, nausea and diarrhea.

There is no definite treatment for Behcet's disease; management includes topical lotions for ulcers, immunosuppressive drugs, corticosteroids and lifestyle changes. Colchicines may be used to reduce symptoms and avoid complications.